Chemistry:PEPITEM
From HandWiki
PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) is an endogenous polypeptide composed of the 14 amino acids 28–41 of the 14.3.3.ζδ protein, which in turn is a 245 amino-acid product of the YWHAZ gene. It has the sequence SVTEQGAELSNEER. PEPITEM has antiinflammatory effects by inhibiting trafficking of T cells into inflamed tissues. Levels of PEPITEM in the body decline with age, diabetes or rheumatoid arthritis, and decreased PEPITEM levels correlates with increases in chronic inflammation and numerous resulting health issues. Administration of synthetic PEPITEM has been suggested as a treatment for various conditions where inflammation plays a role.[1][2][3][4][5][6][7][8]
References
- ↑ "Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease". Nature Medicine 21 (5): 467–475. May 2015. doi:10.1038/nm.3842. PMID 25894827.
- ↑ "PEPITEM/Cadherin 15 Axis Inhibits T Lymphocyte Infiltration and Glomerulonephritis in a Mouse Model of Systemic Lupus Erythematosus". Journal of Immunology 204 (8): 2043–2052. April 2020. doi:10.4049/jimmunol.1900213. PMID 32169847.
- ↑ "PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation". Clinical and Experimental Immunology 212 (1): 1–10. April 2023. doi:10.1093/cei/uxad022. PMID 36891817.
- ↑ "PEPITEM Treatment Ameliorates EAE in Mice by Reducing CNS Inflammation, Leukocyte Infiltration, Demyelination, and Proinflammatory Cytokine Production". International Journal of Molecular Sciences 24 (24). December 2023. doi:10.3390/ijms242417243. PMID 38139072.
- ↑ "Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss". Cell Reports. Medicine 5 (5). May 2024. doi:10.1016/j.xcrm.2024.101574. PMID 38776873.
- ↑ "Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention". npj Aging 10 (1): 33. July 2024. doi:10.1038/s41514-024-00160-6. PMID 39025913.
- ↑ "Prophylactic administration of PEPITEM in experimental autoimmune encephalomyelitis delays disease onset, inhibits leukocyte infiltration, and alleviates severity". International Journal of Clinical and Experimental Pathology 17 (12): 492–505. 2024. doi:10.62347/LTAO2386. PMID 39802871.
- ↑ "PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psoriasis". Pharmacological Research 213. March 2025. doi:10.1016/j.phrs.2025.107624. PMID 39855372.
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