Chemistry:DCG-IV
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Short description: Chemical compound
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| Formula | C7H9NO6 |
| Molar mass | 203.150 g·mol−1 |
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DCG-IV is a research drug which acts as a group-selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).[1] It has potent neuroprotective and anticonvulsant effects in animal studies,[2][3][4][5] as well as showing anti-Parkinsonian effects,[6][7] but also impairs the formation of memories.[8][9]
References
- ↑ "A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord". British Journal of Pharmacology 109 (4): 1169–77. August 1993. doi:10.1111/j.1476-5381.1993.tb13745.x. PMID 8401927.
- ↑ "Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death". European Journal of Pharmacology 256 (1): 109–12. April 1994. doi:10.1016/0014-2999(94)90624-6. PMID 7517889.
- ↑ "Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia". Neuroscience Letters 461 (3): 266–70. September 2009. doi:10.1016/j.neulet.2009.06.056. PMID 19549561.
- ↑ "Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV)". Brain Research 805 (1–2): 138–43. September 1998. doi:10.1016/S0006-8993(98)00698-2. PMID 9733953.
- ↑ "Metabotropic glutamate receptor antagonists and agonists: potential neuroprotectors in diffuse brain injury". Journal of Clinical Neuroscience 13 (10): 1023–7. December 2006. doi:10.1016/j.jocn.2005.11.042. PMID 17113985.
- ↑ "The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat". British Journal of Pharmacology 129 (3): 541–6. February 2000. doi:10.1038/sj.bjp.0703105. PMID 10711353.
- ↑ "DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury". Neuroscience 113 (4): 857–69. 2002. doi:10.1016/S0306-4522(02)00232-4. PMID 12182892.
- ↑ "mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD. induction, in the dentate gyrus in vitro". NeuroReport 8 (3): 687–93. February 1997. doi:10.1097/00001756-199702100-00022. PMID 9106748.
- ↑ "Inhibitory effects of group II mGluR-related drugs on memory performance in mice". Physiology & Behavior 80 (5): 747–58. February 2004. doi:10.1016/j.physbeh.2003.12.010. PMID 14984810.
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