Chemistry:DIDS
From HandWiki
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| Names | |
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| Preferred IUPAC name
2,2′-(Ethene-1,2-diyl)bis(5-isothiocyanatobenzene-1-sulfonic acid) | |
| Other names
5-Isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid
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| Identifiers | |
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3D model (JSmol)
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| Abbreviations | DIDS |
| 6543839 | |
| ChEBI | |
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| KEGG | |
| MeSH | 4,4'-Diisothiocyanostilbene-2,2'-disulfonic+acid |
PubChem CID
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| Properties | |
| C16H10N2O6S4 | |
| Molar mass | 454.50 g·mol−1 |
| Melting point | 400 °C (752 °F; 673 K) |
| log P | 4.72 |
| Acidity (pKa) | -3.21, -1.428, -0.37, 0.23 |
| Basicity (pKb) | 13.77, 14.37, 15.425, 17.21 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
4,4′-Diisothiocyano-2,2′-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor,[1] blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger.[2]
References
- ↑ Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS", Journal of Membrane Biology 92 (3): 195–205, doi:10.1007/BF01869388, PMID 3783658
- ↑ Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster", Biology of Reproduction 61 (2): 452–457, doi:10.1095/biolreprod61.2.452, PMID 10411526
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