Chemistry:Datumetine
From HandWiki
Short description: Chemical compound
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| Formula | C16H21NO3 |
| Molar mass | 275.348 g·mol−1 |
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Datumetine is a tropane alkaloid found in leaves of Datura metel.[1] It is said to modulate NMDA receptor and thus causes memory loss.[2] It also causes epileptic seizures in mice.[2] Docking studies suggest that it fits on both allosteric and orthosteric sites of NMDA receptor.[2] It acts together with other anticholinergic tropane alkaloids of datura to cause amnesia.[citation needed]
See also
References
- ↑ "Isolation and Structure of a New Alkaloid Datumetine from the leaves of Datura metel". Journal of Natural Products 49 (3): 511–513. 2004. doi:10.1021/np50045a023. ISSN 0163-3864.
- ↑ 2.0 2.1 2.2 "Effects of datumetine on hippocampal NMDAR activity". Toxicology Reports 8: 1131–1142. 2021. doi:10.1016/j.toxrep.2021.05.009. PMID 34150523.
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