Chemistry:EF-24
From HandWiki
Short description: Chemical compound
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| Formula | C19H15F2NO |
| Molar mass | 311.332 g·mol−1 |
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EF-24 is a compound that is a synthetic analogue of curcumin, a bioactive phytochemical from turmeric. Curcumin has antioxidant, antibiotic, anti-inflammatory and anti-cancer properties in vitro but has low potency and very poor bioavailability when taken orally, resulting in limited efficacy. EF-24 was developed to try to improve upon these properties, and has been found to be around 10x more potent than curcumin and with much higher systemic bioavailability. It has never been developed for medical use, though research continues to investigate whether it may be useful as an adjuvant treatment for some cancers alongside conventional chemotherapy drugs.[1][2][3][4][5]
References
- ↑ "EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism". Anti-Cancer Drugs 16 (3): 263–75. March 2005. doi:10.1097/00001813-200503000-00005. PMID 15711178.
- ↑ "Highly Active Anticancer Curcumin Analogues". The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Advances in Experimental Medicine and Biology. 595. 2007. pp. 77–103. doi:10.1007/978-0-387-46401-5_2. ISBN 978-0-387-46400-8.
- ↑ "Bioactivities of EF24, a Novel Curcumin Analog: A Review". Frontiers in Oncology 8: 614. 2018. doi:10.3389/fonc.2018.00614. PMID 30619754.
- ↑ "The curcumin analog EF24 is a novel senolytic agent". Aging 11 (2): 771–782. January 2019. doi:10.18632/aging.101787. PMID 30694217.
- ↑ "Dienone Compounds: Targets and Pharmacological Responses". Journal of Medicinal Chemistry 63 (24): 15075–15093. November 2020. doi:10.1021/acs.jmedchem.0c00812. PMID 33146523.
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