Chemistry:EGLU
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Short description: Chemical compound
-%CE%B1-ethylglutamic_acid.svg) | |
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| Formula | C7H13NO4 |
| Molar mass | 175.184 g·mol−1 |
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EGLU ((2S)-α-ethylglutamic acid ) is a drug that is used in neuroscience research. It was one of the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and so has been useful in the characterization and study of this receptor subfamily.[1][2][3][4][5][6][7]
References
- ↑ "Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord". Neuropharmacology 35 (8): 1029–35. 1996. doi:10.1016/S0028-3908(96)00048-2. PMID 9121605.
- ↑ "Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro". European Journal of Pharmacology 366 (2–3): 151–8. February 1999. doi:10.1016/S0014-2999(98)00918-2. PMID 10082195.
- ↑ "Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception". Neuropharmacology 40 (3): 319–26. March 2001. doi:10.1016/S0028-3908(00)00160-X. PMID 11166324.
- ↑ "Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat". Brain Research 1027 (1–2): 151–60. November 2004. doi:10.1016/j.brainres.2004.08.052. PMID 15494166.
- ↑ "Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo". Neuroscience 146 (1): 202–12. April 2007. doi:10.1016/j.neuroscience.2007.01.049. PMID 17346894.
- ↑ "Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment". Behavioural Brain Research 191 (1): 62–6. August 2008. doi:10.1016/j.bbr.2008.03.010. PMID 18433894.
- ↑ "A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory". Neuroscience 158 (1): 149–58. January 2009. doi:10.1016/j.neuroscience.2008.07.045. PMID 18722513.
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