Chemistry:Evocalcet
From HandWiki
Short description: Chemical compound
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| Trade names | Orkedia |
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| Formula | C24H26N2O2 |
| Molar mass | 374.484 g·mol−1 |
Evocalcet (trade name Orkedia) is a drug for the treatment of hyperparathyroidism.[1] It acts as a calcium-sensing receptor agonist.[2]
In 2018, it was approved in Japan for treatment of secondary hyperparathyroidism in patients on dialysis.[3]
References
- ↑ "A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro". PLOS ONE 13 (4): e0195316. 2018. doi:10.1371/journal.pone.0195316. PMID 29614098. Bibcode: 2018PLoSO..1395316K.
- ↑ "Discovery of evocalcet, a next-generation calcium-sensing receptor agonist for the treatment of hyperparathyroidism". Bioorganic & Medicinal Chemistry Letters 28 (11): 2055–2060. June 2018. doi:10.1016/j.bmcl.2018.04.055. PMID 29724589.
- ↑ "Kyowa Hakko Kirin Launches Orkedia Tablets (Evocalcet) for the Treatment of Secondary Hyperparathyroidism in Patients on Maintenance Dialysis in Japan" (Press release). Kyowa Hakko Kirin. May 22, 2018.
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