Chemistry:FLS-359
From HandWiki
FLS-359 is a drug which acts as a selective allosteric inhibitor of the enzyme sirtuin 2 (SIRT2). It has moderate potency, inhibiting SIRT2 with an IC50 of 3 μM, and shows broad-spectrum antiviral effects against both RNA and DNA viruses including hepatitis B and cytomegalovirus.[1][2][3]
References
- ↑ "An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity". The Journal of Clinical Investigation 133 (12). June 2023. doi:10.1172/JCI158978. PMID 37317966.
- ↑ "An allosteric inhibitor of sirtuin 2 blocks hepatitis B virus covalently closed circular DNA establishment and its transcriptional activity". Antiviral Research 226. June 2024. doi:10.1016/j.antiviral.2024.105888. PMID 38641024.
- ↑ "Generation of a panel of mutants that are resistant to standard of care therapies in a clinically relevant strain of human cytomegalovirus for drug resistance profiling". Antiviral Research 241. September 2025. doi:10.1016/j.antiviral.2025.106237. PMID 40653174.
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