Chemistry:FOXO4-DRI

From HandWiki

FOXO4-DRI is a synthetic peptide derivative that is described as an all D-enantiomer retro-inverso peptide[1] having the sequence H-ltlrkepaseiaqsileaysqngwanrrsggkrppprrrqrrkkrg-OH.[2] It blocks the activity of Forkhead box protein O4 (FOXO4), a transcription factor which is elevated in senescent cells, and helps maintain their viability. Blocking FOXO4 causes senescent cells to undergo apoptosis without affecting healthy cells around them, and has anti-aging effects which may have potential applications in the treatment of numerous age-related diseases, as well as an adjunct to treatment for certain forms of cancer.[3][4][5][6][7][8][9][10]

See also

  • Tertomotide

References

  1. ↑ "Recent Applications of Retro-Inverso Peptides". International Journal of Molecular Sciences 22 (16): 8677. August 2021. doi:10.3390/ijms22168677. PMID 34445382. 
  2. ↑ "Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging". Cell 169 (1): 132–147.e16. March 2017. doi:10.1016/j.cell.2017.02.031. PMID 28340339. 
  3. ↑ "Rejuvenation by Therapeutic Elimination of Senescent Cells". Cell 169 (1): 3–5. March 2017. doi:10.1016/j.cell.2017.03.014. PMID 28340347. 
  4. ↑ "Cellular senescence as a therapeutic target to improve renal transplantation outcome". Pharmacological Research 130: 322–330. April 2018. doi:10.1016/j.phrs.2018.02.015. PMID 29471104. 
  5. ↑ "FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice". Aging 12 (2): 1272–1284. January 2020. doi:10.18632/aging.102682. PMID 31959736. 
  6. ↑ "Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis". JCI Insight 6 (23). December 2021. doi:10.1172/jci.insight.146334. PMID 34877934. 
  7. ↑ "FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice". Naunyn-Schmiedeberg's Archives of Pharmacology 396 (10): 2393–2403. October 2023. doi:10.1007/s00210-023-02452-2. PMID 37074394. 
  8. ↑ "FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells". Experimental Gerontology 195. October 2024. doi:10.1016/j.exger.2024.112522. PMID 39025385. 
  9. ↑ "FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation". Communications Biology 8 (1). February 2025. doi:10.1038/s42003-025-07738-0. PMID 39994346. 
  10. ↑ "The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI". Nature Communications 16 (1). July 2025. doi:10.1038/s41467-025-60844-9. PMID 40593617. Bibcode: 2025NatCo..16.5672B. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:FOXO4-DRI&oldid=4242849"