Chemistry:FP802
From HandWiki
FP802 is a chemical compound which has neuroprotective effects. It is a TwinF interface inhibitor which prevents the NMDA receptor from forming a complex with the signalling factor TRPM4, and so blocks NMDA-induced neurotoxicity but without disrupting basal levels of NMDA signalling. It shows beneficial effects in animal models of conditions such as Alzheimer's disease and amyotrophic lateral sclerosis.[1][2][3][4][5]
References
- ↑ "TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS". Cell Reports. Medicine 5 (2). February 2024. doi:10.1016/j.xcrm.2024.101413. PMID 38325382.
- ↑ "TwinF interface inhibitor FP802 prevents retinal ganglion cell loss in a mouse model of amyotrophic lateral sclerosis". Acta Neuropathologica Communications 12 (1). September 2024. doi:10.1186/s40478-024-01858-0. PMID 39267142.
- ↑ "Pharmacological Targeting of the NMDAR/TRPM4 Death Signaling Complex with a TwinF Interface Inhibitor Prevents Excitotoxicity-Associated Dendritic Blebbing and Organelle Damage". Cells 14 (3): 195. January 2025. doi:10.3390/cells14030195. PMID 39936986.
- ↑ "Inhba, Homer1 and Bdnf are major targets of transcriptomic dysregulation by neurodegenerative disease-associated excitotoxic NMDA receptor signaling". Communications Biology 8 (1). December 2025. doi:10.1038/s42003-025-09074-9. PMID 41339520.
- ↑ "The NMDAR/TRPM4 death complex is a major promoter of disease progression in the 5xFAD mouse model of Alzheimer's disease". Molecular Psychiatry 31 (2): 635–648. February 2026. doi:10.1038/s41380-025-03143-5. PMID 40858778.
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