Chemistry:GPR120 compound A
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| Formula | C19H23ClF3NO3 |
| Molar mass | 405.84 g·mol−1 |
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GPR120 compound A is an experimental drug which acts as a potent and highly selective agonist for the free fatty acid receptor FFAR4 (GPR120). It has antiinflammatory effects and regulates glucose homeostasis and insulin release. It has been researched in animal models of diabetes. GPR120 compound A has also been referred to as GPR120 agonist III but this has also been used in some papers to refer to the older compound TUG-891, which may cause confusion about which drug was used if the chemical structure or other unique identifiers are not specifically stated.[1][2][3]
References
- ↑ "A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice". Nature Medicine 20 (8): 942–947. August 2014. doi:10.1038/nm.3614. PMID 24997608.
- ↑ "Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists". ACS Medicinal Chemistry Letters 8 (1): 49–54. January 2017. doi:10.1021/acsmedchemlett.6b00360. PMID 28105274.
- ↑ "Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice". Acta Pharmacologica Sinica 41 (10): 1337–1347. October 2020. doi:10.1038/s41401-020-0435-1. PMID 32555509.
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