Chemistry:H-151

From HandWiki

H-151 is an experimental drug which acts as an irreversible antagonist of the stimulator of interferon genes (STING) protein. It has antiinflammatory and antiviral effects by reducing cytokine signalling, and has potential application in numerous disease states in which inflammation plays a role.[1][2][3][4][5][6][7][8][9][10][11]

See also

References

  1. ↑ "Targeting STING with covalent small-molecule inhibitors". Nature 559 (7713): 269–273. July 2018. doi:10.1038/s41586-018-0287-8. PMID 29973723. Bibcode: 2018Natur.559..269H. http://infoscience.epfl.ch/record/260075. 
  2. ↑ "STING, a promising target for small molecular immune modulator: A review". European Journal of Medicinal Chemistry 211. February 2021. doi:10.1016/j.ejmech.2020.113113. PMID 33360799. 
  3. ↑ "The cGAS-STING pathway drives type I IFN immunopathology in COVID-19". Nature 603 (7899): 145–151. March 2022. doi:10.1038/s41586-022-04421-w. PMID 35045565. Bibcode: 2022Natur.603..145D. 
  4. ↑ "H151, A Small Molecule Inhibitor of Sting as a Novel Therapeutic in Intestinal Ischemia-Reperfusion Injury". Shock 58 (3): 241–250. September 2022. doi:10.1097/SHK.0000000000001968. PMID 35959789. 
  5. ↑ "Small molecules targeting cGAS-STING pathway for autoimmune disease". European Journal of Medicinal Chemistry 238. August 2022. doi:10.1016/j.ejmech.2022.114480. PMID 35635952. 
  6. ↑ "Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway". Virus Research 343. May 2024. doi:10.1016/j.virusres.2024.199344. PMID 38431054. 
  7. ↑ "H-151, a Selective STING Inhibitor, Has Potential as a Treatment for Neovascular Age-Related Macular Degeneration". Investigative Ophthalmology & Visual Science 65 (8): 16. July 2024. doi:10.1167/iovs.65.8.16. PMID 38980271. 
  8. ↑ "STING facilitates the development of radiation-induced lung injury via regulating the PERK/eIF2α pathway". Translational Lung Cancer Research 13 (11): 3010–3025. November 2024. doi:10.21037/tlcr-24-649. PMID 39670000. 
  9. ↑ "H-151 attenuates lipopolysaccharide-induced acute kidney injury by inhibiting the STING-TBK1 pathway". Renal Failure 46 (2). December 2024. doi:10.1080/0886022X.2024.2363591. PMID 38856314. 
  10. ↑ "STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions". CNS Neuroscience & Therapeutics 30 (12). December 2024. doi:10.1111/cns.70106. PMID 39698742. 
  11. ↑ "Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage". Neuroscience Bulletin 41 (3): 359–373. March 2025. doi:10.1007/s12264-024-01334-8. PMID 39676140. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:H-151&oldid=4245494"