Chemistry:HEC96719
From HandWiki
Short description: Chemical compound
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| Formula | C29H22Cl2N2O5 |
| Molar mass | 549.40 g·mol−1 |
HEC96719 is a tricyclic farnesoid X receptor agonist developed for non-alcoholic steatohepatitis.[1][2][3]
References
- ↑ Cao, Shengtian; Yang, Xinye; Zhang, Zheng; Wu, Junwen; Chi, Bo; Chen, Hong; Yu, Jianghong; Feng, Shanshan et al. (February 2022). "Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis". European Journal of Medicinal Chemistry 230: 114089. doi:10.1016/j.ejmech.2021.114089. PMID 34998040.
- ↑ Zhang, Na; Fan, Tianyun; Zhao, Liping; Li, Yiming; Bao, Yunyang; Ma, Xican; Mei, Yuheng; Wang, Yanxiang et al. (January 2023). "Discovery and development of palmatine analogues as anti-NASH agents by activating farnesoid X receptor (FXR)". European Journal of Medicinal Chemistry 245 (Pt 1): 114886. doi:10.1016/j.ejmech.2022.114886. PMID 36347091.
- ↑ Lu, Ran; Liu, Ye; Hong, Tianpei (April 2023). "Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review". Diabetes, Obesity and Metabolism 25 (S1): 13–26. doi:10.1111/dom.15014. PMID 36775938.
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