Chemistry:Hydrangenol

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Hydrangenol
Chemical structure of hydrangenol
Names
Preferred IUPAC name
8-Hydroxy-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
KEGG
UNII
Properties
C15H12O4
Molar mass 256.25 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
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Hydrangenol is a dihydroisocoumarin. It can be found in Hydrangea macrophylla, as well as its 8-O-glucoside.[1] (−)-Hydrangenol 4′-O-glucoside[2] and (+)-hydrangenol 4′-O-glucoside[3] can be found in Hydrangeae Dulcis Folium, the processed leaves of H. macrophylla var. thunbergii.

References

  1. Matsuda, Hisashi; Simoda, Hiroshi; Yamahara, Johji; Yoshikawa, Masayuki (1999). "Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla Seringe var. thunbergii Makino on passive cutaneous anaphylaxis reaction in rats". Biological & Pharmaceutical Bulletin 22 (8): 870–872. doi:10.1248/bpb.22.870. INIST:1959604. PMID 10480329. 
  2. Yoshikawa, M; Uchida, E; Chatani, N; Kobayashi, H; Naitoh, Y; Okuno, Y; Matsuda, H; Yamahara, J et al. (1992). "Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3′-O-glucoside and (−)-hydrangenol 4′-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium". Chemical & Pharmaceutical Bulletin 40 (12): 3352–3354. doi:10.1248/cpb.40.3352. PMID 1363465. 
  3. Yoshikawa, M; Matsuda, H; Shimoda, H; Shimada, H; Harada, E; Naitoh, Y; Miki, A; Yamahara, J et al. (1996). "Development of bioactive functions in Hydrangeae Dulcis Folium. V. On the antiallergic and antimicrobial principles of Hydrangeae Dulcis Folium. (2). Thunberginols C, D, and E, thunberginol G 3′-O-glucoside, (−)-hydrangenol 4′-O-glucoside, and (+)-hydrangenol 4′-O-glucoside". Chemical & Pharmaceutical Bulletin 44 (8): 1440–1447. doi:10.1248/cpb.44.1440. INIST:3226693. PMID 8795265.