Chemistry:Hydrogen atom abstraction
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Short description: Any chemical reaction which swaps a hydrogen radical between two molecules
In chemistry, a hydrogen atom abstraction or hydrogen atom transfer (HAT) is any chemical reaction in which a hydrogen free radical (neutral hydrogen atom) is abstracted from a substrate according to the general equation:
- [math]\ce{ X^\bullet{} + H-Y -> X-H{} + Y^\bullet }[/math]
Examples of HAT reactions are oxidative reactions in general, hydrocarbon combustion, and reactions involving cytochrome P450 containing an iron(V)-oxo unit. The abstractor (X•) is usually a radical species itself, but it may also be a closed-shell species such as chromyl chloride. HAT can take place through proton-coupled electron transfer.[1] A synthetic example is found in iron zeolites, which stabilize alpha-oxygen.[2][3]
References
- ↑ Lai W.; Li C.; Chen H.; Shaik S. (2012). "Hydrogen-Abstraction Reactivity Patterns from A to Y: The Valence Bond Way". Angew. Chem. Int. Ed. 51 (23): 5556–5578. doi:10.1002/anie.201108398. PMID 22566272.
- ↑ Snyder, Benjamin E. R.; Vanelderen, Pieter; Bols, Max L.; Hallaert, Simon D.; Böttger, Lars H.; Ungur, Liviu; Pierloot, Kristine; Schoonheydt, Robert A. et al. (August 2016). "The active site of low-temperature methane hydroxylation in iron-containing zeolites" (in En). Nature 536 (7616): 317–321. doi:10.1038/nature19059. ISSN 0028-0836. PMID 27535535. Bibcode: 2016Natur.536..317S.
- ↑ Snyder, Benjamin E. R.; Bols, Max L.; Schoonheydt, Robert A.; Sels, Bert F.; Solomon, Edward I. (2017-12-19). "Iron and Copper Active Sites in Zeolites and Their Correlation to Metalloenzymes" (in en). Chemical Reviews 118 (5): 2718–2768. doi:10.1021/acs.chemrev.7b00344. ISSN 0009-2665. PMID 29256242. https://lirias.kuleuven.be/handle/123456789/627682.
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