Chemistry:IU1

From HandWiki

IU1 is a drug used in scientific research which acts as a selective inhibitor of the ubiquitin-specific processing protease enzyme USP14.[1] It is of interest in anti-cancer and antiviral research and also as a potential anti-aging drug. Numerous derivatives of IU1 have been developed with up to 10x the potency of IU1 as USP14 inhibitors,[2][3] but IU1 remains the most widely used compound in research in this area.[4][5][6][7][8][9][10]

References

  1. ↑ "Enhancement of proteasome activity by a small-molecule inhibitor of USP14". Nature 467 (7312): 179–84. September 2010. doi:10.1038/nature09299. PMID 20829789. Bibcode: 2010Natur.467..179L. 
  2. ↑ "Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade". Cell Research 28 (12): 1186–1194. December 2018. doi:10.1038/s41422-018-0091-x. PMID 30254335. 
  3. ↑ "An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons". The Journal of Biological Chemistry 292 (47): 19209–19225. November 2017. doi:10.1074/jbc.M117.815126. PMID 28972160. 
  4. ↑ "A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication". Virus Research 165 (1): 103–106. April 2012. doi:10.1016/j.virusres.2012.01.009. PMID 22306365. 
  5. ↑ "Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases". International Journal of Molecular Sciences 22 (12): 6213. June 2021. doi:10.3390/ijms22126213. PMID 34207520. 
  6. ↑ "USP14: Structure, Function, and Target Inhibition". Frontiers in Pharmacology 12. 2022. doi:10.3389/fphar.2021.801328. PMID 35069211. 
  7. ↑ "Inhibition of USP14 Suppresses ROS-dependent Ferroptosis and Alleviates Renal Ischemia/Reperfusion Injury". Cell Biochemistry and Biophysics 81 (1): 87–96. March 2023. doi:10.1007/s12013-022-01107-y. PMID 36255562. 
  8. ↑ "USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice". CNS Neuroscience & Therapeutics 29 (11): 3612–3623. November 2023. doi:10.1111/cns.14292. PMID 37269080. 
  9. ↑ "Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent manner". Autophagy 20 (12): 2752–2768. December 2024. doi:10.1080/15548627.2024.2389607. PMID 39113571. 
  10. ↑ "USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5". Theranostics 15 (6): 2293–2314. 2025. doi:10.7150/thno.103629. PMID 39990235. 



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