Chemistry:Indusatumab vedotin
From HandWiki
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Human |
| Target | Guanylate cyclase 2C |
| Clinical data | |
| Other names | MLN-0264, 5F9vcMMAE |
| Routes of administration | Intravenous |
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| Molar mass | ~150 kg/mol |
Indusatumab vedotin (MLN-0264) is an antibody-drug conjugate that is under development for the treatment of pancreatic cancer[1] and other gastrointestinal cancers.[2] It consists of a monoclonal antibody (indusatumab) that targets the enzyme guanylate cyclase 2C which is present in some cancers, linked to an average of three to four molecules of the chemotherapeutic agent monomethyl auristatin E (MMAE).[3]
It was in Phase II clinical trials (As of February 2016). The trials were terminated in 2017 because of insufficient efficacy.[1][2][4]
References
- ↑ 1.0 1.1 Clinical trial number NCT02202785 for "A Study of MLN0264 in Patients With Pancreatic Cancer" at ClinicalTrials.gov
- ↑ 2.0 2.1 Clinical trial number NCT02202759 for "A Study of MLN0264 in Patients With Cancer of the Stomach or Gastroesophageal Junction" at ClinicalTrials.gov
- ↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended INN: List 74". WHO Drug Information 29 (3): 402–3. 2015. https://www.who.int/entity/medicines/publications/druginformation/innlists/RL74.pdf.
- ↑ "A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C". Invest New Drugs 35 (5): 634–641. 2017. doi:10.1007/s10637-017-0473-9. PMID 28527133.
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