Chemistry:Isocycloseram
Isocycloseram is a chemical compound discovered by Syngenta which acts as an insecticide. It acts as a noncompetitive antagonist of invertebrate γ-aminobutyric acid (GABA)-gated chloride channels, producing uncontrolled neuronal excitation leading to paralysis and death in various species of pest insects, but with high selectivity over mammalian GABA receptors. As with all insecticides, unwanted toxicity to desirable non targeted insects such as pollinators can be an issue, requiring strategic application and use.[1][2][3][4]
Uses
Pesticide
In November 2025, the U.S. Environmental Protection Agency approved agricultural use of isocycloseram as a pesticide. Because the compound is defined as a PFAS by the European Union, OECD, and several U.S. states, concerns were raised about health and environment impacts of the approval.[5][6] The U.S. EPA does not consider chemicals with a single fluorinated carbon like isocycloseram to be PFAS and contends that "molecules with only one fluorinated carbon generally lack the persistence and bioaccumulation properties that are commonly associated with forever chemicals".[7]
References
- ↑ "The discovery of isocycloseram: A novel isoxazoline insecticide". Recent Highlights in the Discovery and Optimization of Crop Protection Products. 2021. pp. 165–212. doi:10.1016/B978-0-12-821035-2.00008-5. ISBN 978-0-12-821035-2.
- ↑ "The mode of action of isocycloseram: A novel isoxazoline insecticide". Pesticide Biochemistry and Physiology 187. October 2022. doi:10.1016/j.pestbp.2022.105217. PMID 36127059. Bibcode: 2022PBioP.18705217B.
- ↑ "Isocycloseram, a novel isoxazoline insecticide seed treatment for protection of wheat and barley and mortality of wireworms, Limonius californicus (Coleoptera: Elateridae)". Journal of Economic Entomology 117 (5): 1926–1937. October 2024. doi:10.1093/jee/toae170. PMID 39082981.
- ↑ "Efficacy and utility of isocycloseram a novel isoxazoline insecticide against urban pests and public health disease vectors". Pest Management Science 81 (2): 978–989. February 2025. doi:10.1002/ps.8497. PMID 39535487. Bibcode: 2025PMSci..81..978S.
- ↑ Held, Lisa (2025-12-10). "What to Know About PFAS in Pesticides" (in en). https://civileats.com/2025/12/10/what-to-know-about-pfas-in-pesticides/.
- ↑ Kluger, Jeffrey. "EPA Is Embracing PFAS Pesticides. These Are The Health Risks" (in en). TIME. https://time.com/7336883/epa-pfas-pesticides-health-risks/.
- ↑ US EPA, OCSPP (2025-11-03). "Pesticides Containing a Single Fluorinated Carbon" (in en). https://www.epa.gov/ingredients-used-pesticide-products/pesticides-containing-single-fluorinated-carbon.
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