Chemistry:Isostrychnine
From HandWiki
Isostrychnine is a monoterpenoid indole alkaloid and a structural isomer of strychnine. It is a secondary plant metabolite and may have antitumor activity.
Occurrence
Isostrychnine has been isolated from plant extracts of Strychnos species (e.g the seeds of Strychnos nux-vomica (strychnine tree) or the roots of Strychnos icaja).[1][2] It is also present in Strychnos ignatii.[2]
Pharmacology
One study observed inhibitory effects against Hep G2 cell proliferation.[3] Another study found isostrychnine arrested the growth of the human hepatocarcinoma cell line SMMC 7721.[4]
References
- ↑ Frédérich, Michel; Pauw, Marie-Claire De; Llabrès, Gabriel; Tits, Monique; Hayette, Marie-Pierre; Brandt, Viviane; Penelle, Jacques; Mol, Patrick De et al. (2000). "New Antimalarial and Cytotoxic Sungucine Derivatives from Strychnos icaja Roots" (in en). Planta Medica 66 (03): 262–269. doi:10.1055/s-2000-8559. ISSN 0032-0943. http://www.thieme-connect.de/DOI/DOI?10.1055/s-2000-8559.
- ↑ 2.0 2.1 PubChem. "Isostrychnine" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/11024113.
- ↑ Deng, Xu-Kun; Yin, Wu; Li, Wei-Dong; Yin, Fang-Zhou; Lu, Xiao-Yu; Zhang, Xiao-Chun; Hua, Zi-Chun; Cai, Bao-Chang (2006-06-30). "The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism". Journal of Ethnopharmacology 106 (2): 179–186. doi:10.1016/j.jep.2005.12.021. ISSN 0378-8741. https://www.sciencedirect.com/science/article/pii/S0378874105008421.
- ↑ Yin, Wu; Deng, Xu-Kun; Yin, Fang-Zhou; Zhang, Xiao-Chun; Cai, Bao-Chang (2007-09-01). "The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells". Food and Chemical Toxicology 45 (9): 1700–1708. doi:10.1016/j.fct.2007.03.004. ISSN 0278-6915. https://www.sciencedirect.com/science/article/pii/S0278691507000944.
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