Chemistry:J-2156

From HandWiki

J-2156 is a chemical compound which was one of the first compounds developed that acts as an agonist at somatostatin receptor 4. It has analgesic and anti-hyperalgesic effects and is widely used in research into the role of SST4 receptors in pain perception and other neurological functions.[1][2][3][4][5][6][7][8][9][10]

See also

  • Mazisotine
  • NNC 26-9100

References

  1. ↑ "Superagonism at the human somatostatin receptor subtype 4". The Journal of Pharmacology and Experimental Therapeutics 312 (1): 332–338. January 2005. doi:10.1124/jpet.104.075531. PMID 15333679. 
  2. ↑ "Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models". European Journal of Pharmacology 539 (1–2): 71–75. June 2006. doi:10.1016/j.ejphar.2006.03.082. PMID 16697366. 
  3. ↑ "Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse". European Journal of Pharmacology 578 (2–3): 313–322. January 2008. doi:10.1016/j.ejphar.2007.09.033. PMID 17961545. 
  4. ↑ "Somatostatin receptor subtype 4 activation is involved in anxiety and depression-like behavior in mouse models". Neuropharmacology 101: 204–215. February 2016. doi:10.1016/j.neuropharm.2015.09.021. PMID 26387439. 
  5. ↑ "The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain". Frontiers in Pharmacology 9. 2018. doi:10.3389/fphar.2018.00495. PMID 29867498. 
  6. ↑ "J-2156, a somatostatin receptor type 4 agonist, alleviates mechanical hyperalgesia in a rat model of chronic low back pain". Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 117. September 2019. doi:10.1016/j.biopha.2019.109056. PMID 31181441. 
  7. ↑ "Characterization of Neurons Expressing the Novel Analgesic Drug Target Somatostatin Receptor 4 in Mouse and Human Brains". International Journal of Molecular Sciences 21 (20): 7788. October 2020. doi:10.3390/ijms21207788. PMID 33096776. 
  8. ↑ "Small molecule somatostatin receptor subtype 4 (sst4) agonists are novel anti-inflammatory and analgesic drug candidates". Neuropharmacology 178. November 2020. doi:10.1016/j.neuropharm.2020.108198. PMID 32739276. 
  9. ↑ "Structural insights into ligand recognition and selectivity of somatostatin receptors". Cell Research 32 (8): 761–772. August 2022. doi:10.1038/s41422-022-00679-x. PMID 35739238. 
  10. ↑ "J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine". Frontiers in Pharmacology 15. 2024. doi:10.3389/fphar.2024.1346801. PMID 38318132. 



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