Biology:Somatostatin receptor 4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.

See also

• Somatostatin receptor

Further reading

• "Somatostatin and its receptor family". Frontiers in Neuroendocrinology 20 (3): 157–98. July 1999. doi:10.1006/frne.1999.0183. PMID 10433861. 
• "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America 89 (1): 251–5. January 1992. doi:10.1073/pnas.89.1.251. PMID 1346068. Bibcode: 1992PNAS...89..251Y. 
• "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20". Molecular Pharmacology 43 (6): 894–901. June 1993. PMID 8100352. 
• "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics 17 (3): 785–6. September 1993. doi:10.1006/geno.1993.1410. PMID 8244401. 
• "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochemical and Biophysical Research Communications 195 (2): 844–52. September 1993. doi:10.1006/bbrc.1993.2122. PMID 8373420. 
• "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters 331 (1–2): 53–9. September 1993. doi:10.1016/0014-5793(93)80296-7. PMID 8405411. 
• "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449–52. February 1993. doi:10.1006/geno.1993.1088. PMID 8449518. 
• "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4". Biochemical and Biophysical Research Communications 193 (2): 648–52. June 1993. doi:10.1006/bbrc.1993.1673. PMID 8512564. 
• "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications 232 (1): 157–63. March 1997. doi:10.1006/bbrc.1997.6252. PMID 9125122. 
• "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics 42 (3): 499–506. June 1997. doi:10.1006/geno.1997.4763. PMID 9205124. 
• "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". European Journal of Clinical Investigation 27 (8): 639–44. August 1997. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. 
• "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Molecular Endocrinology 13 (1): 82–90. January 1999. doi:10.1210/mend.13.1.0220. PMID 9892014. 
• "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors". Journal of Nuclear Medicine 41 (4): 636–42. April 2000. PMID 10768564. 
• "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism 86 (5): 2161–9. May 2001. doi:10.1210/jcem.86.5.7489. PMID 11344221. 
• "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clinical and Experimental Immunology 125 (1): 71–9. July 2001. doi:10.1046/j.1365-2249.2001.01577.x. PMID 11472428. 
• "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica 26 (3): 175–9. September 2001. PMID 11753241. 
• "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv 440 (5): 461–75. May 2002. doi:10.1007/s00428-002-0609-x. PMID 12021920. 

External links

• "Somatostatin Receptors: sst₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2441. 
• somatostatin+receptor+subtype-4 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.