Chemistry:JNJ-10397049

JNJ-10397049
Clinical data
ATC code	none;
Identifiers
	IUPAC name 1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)urea;
CAS Number	708275-58-5 ;
PubChem CID	9869934;
IUPHAR/BPS	1701;
ChemSpider	8045625 ;
UNII	1B419P24AV;
ChEMBL	ChEMBL359632;
Chemical and physical data
Formula	C19H20Br2N2O3
Molar mass	484.188 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES BrC1=CC=C(NC(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)=O)C(Br)=C1;
	InChI InChI=1S/C19H20Br2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1 ; Key:RBKIJGLHFFQHBE-IRXDYDNUSA-N ;

Short description: Chemical compound

JNJ-10397049 is a potent and highly selective OX₂ receptor antagonist. In animals, JNJ-10397049 was found to have sleep-promoting effects and to attenuate the reinforcing effects of ethanol.^[1]^[2]

References

↑ "Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat". The Journal of Pharmacology and Experimental Therapeutics 330 (1): 142–51. July 2009. doi:10.1124/jpet.109.152009. PMID 19363060.
↑ "Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement". Psychopharmacology 215 (1): 191–203. May 2011. doi:10.1007/s00213-010-2127-x. PMID 21181123.

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Clinical data

ATC code	none
Identifiers
IUPAC name 1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)urea
CAS Number	708275-58-5^Y
PubChem CID	9869934
IUPHAR/BPS	1701
ChemSpider	8045625^N
UNII	1B419P24AV
ChEMBL	ChEMBL359632
Chemical and physical data
Formula	C₁₉H₂₀Br₂N₂O₃
Molar mass	484.188 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES BrC1=CC=C(NC(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)=O)C(Br)=C1
InChI InChI=1S/C19H20Br2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1^N Key:RBKIJGLHFFQHBE-IRXDYDNUSA-N^N