Chemistry:JNJ-3792165
From HandWiki
Short description: Chemical compound
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| Formula | C19H17Cl2N3O |
| Molar mass | 374.27 g·mol−1 |
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JNJ-3792165 is a chemical compound which acts as a small-molecule antagonist of the previously orphan receptor GPR139. It has been shown to modulate dopamine release in the brain via interaction with the Dopamine receptor D2, and increases the effect of morphine at the mu opioid receptor.[1][2][3][4][5]
References
- ↑ "Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro". Frontiers in Pharmacology 9: 157. 2018. doi:10.3389/fphar.2018.00157. PMID 29599718.
- ↑ "GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact". Frontiers in Neuroscience 13: 281. 2019. doi:10.3389/fnins.2019.00281. PMID 30971885.
- ↑ "Pharmacology and function of the orphan GPR139 G protein-coupled receptor". Basic & Clinical Pharmacology & Toxicology 126 (Suppl 6): 35–46. June 2020. doi:10.1111/bcpt.13263. PMID 31132229.
- ↑ "Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139". Cell Research 32 (2): 210–213. February 2022. doi:10.1038/s41422-021-00591-w. PMID 34916631.
- ↑ "Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139". European Journal of Pharmacology 943: 175553. March 2023. doi:10.1016/j.ejphar.2023.175553. PMID 36736525.
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