Chemistry:JTK-109
From HandWiki
JTK-109 is an antiviral drug which acts as a NS5B RNA-dependent RNA polymerase inhibitor. It was initially developed for the treatment of Hepatitis C, but also shows activity against caliciviruses such as norovirus.[1][2][3][4]
References
- ↑ "Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109". Journal of Medicinal Chemistry 49 (15): 4721–4736. July 2006. doi:10.1021/jm060269e. PMID 16854079.
- ↑ "Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety". Bioorganic & Medicinal Chemistry Letters 17 (11): 3181–3186. June 2007. doi:10.1016/j.bmcl.2007.03.027. PMID 17383878.
- ↑ "Broad-spectrum non-nucleoside inhibitors for caliciviruses". Antiviral Research 146: 65–75. October 2017. doi:10.1016/j.antiviral.2017.07.014. PMID 28757394. https://orca.cardiff.ac.uk/id/eprint/104974/.
- ↑ "Norovirus antivirals: Where are we now?". Medicinal Research Reviews 39 (3): 860–886. May 2019. doi:10.1002/med.21545. PMID 30584800.
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