Chemistry:Kynapcin
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Short description: Class of chemical compounds
right|thumb|Skeletal formula of kynapcin-24 Kynapcin is a general name for a number of dibenzofuranyl derivatives of the molecule polyozellin, present in the fungus Polyozellus multiplex. Like polyozellin, some kynapcins inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins including amyloid precursor protein. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.[1] Several kynapcins have been found in P. multiplex, each with different chemical properties, including kynapcin-12,[2] kynapcin-13 and -28,[3] and -24.[4] A total synthesis of kynapcin-24 was achieved in 2009.[5]
References
- ↑ "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics 50 (9): 773–777. 1997. doi:10.7164/antibiotics.50.773. PMID 9360624.
- ↑ "Kynapcin-12, a new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase". The Journal of Antibiotics 53 (7): 714–719. 2000. doi:10.7164/antibiotics.53.714. PMID 10994814.
- ↑ "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex". The Journal of Antibiotics 55 (7): 623–628. 2002. doi:10.7164/antibiotics.55.623. PMID 12243451.
- ↑ "A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex". Journal of Natural Products 65 (1): 76–78. 2002. doi:10.1021/np010194b. PMID 11809072.
- ↑ "The first total synthesis of kynapcin-24 by palladium catalysis". Synthesis 2009 (7): 1175–1179. 2009. doi:10.1055/s-0028-1087998.
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