Chemistry:Polyozellin

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Polyozellin
Polyozellin.svg
Names
Preferred IUPAC name
2,3,8,9-Tetrahydroxybenzo[1,2-b:4,5-b′]bis([1]benzofuran)-6,12-diyl diacetate
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
Properties
C22H14O10
Molar mass 438.344 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Polyozellin is a chemical which occurs in the mushroom Polyozellus multiplex. It inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.[1] Structurally related dibenzofuranyl derivatives of polyozellin are known as kynapcins.[2]

References

  1. "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics 50 (9): 773–77. 1997. doi:10.7164/antibiotics.50.773. PMID 9360624. 
  2. "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex". The Journal of Antibiotics 55 (7): 623–28. 2002. doi:10.7164/antibiotics.55.623. PMID 12243451.