Chemistry:Polyozellin
From HandWiki
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| Preferred IUPAC name
2,3,8,9-Tetrahydroxybenzo[1,2-b:4,5-b′]bis([1]benzofuran)-6,12-diyl diacetate | |
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| Properties | |
| C22H14O10 | |
| Molar mass | 438.344 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Polyozellin is a chemical which occurs in the mushroom Polyozellus multiplex. It inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.[1] Structurally related dibenzofuranyl derivatives of polyozellin are known as kynapcins.[2]
References
- ↑ "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics 50 (9): 773–77. 1997. doi:10.7164/antibiotics.50.773. PMID 9360624.
- ↑ "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex". The Journal of Antibiotics 55 (7): 623–28. 2002. doi:10.7164/antibiotics.55.623. PMID 12243451.
