Chemistry:L-817818
From HandWiki
L-817818 is a chemical compound which acts as an agonist at somatostatin receptor 5. It has neuroprotective effects in animal models and modulates insulin release.[1][2][3][4][5]
References
- ↑ "Identification and characterization of subtype selective somatostatin receptor agonists". Journal of Physiology, Paris 94 (3–4): 211–215. 2000. doi:10.1016/s0928-4257(00)00215-1. PMID 11087999.
- ↑ "Activation of somatostatin receptor (sst 5) protects the rat retina from AMPA-induced neurotoxicity". Neuropharmacology 58 (1): 297–303. January 2010. doi:10.1016/j.neuropharm.2009.06.028. PMID 19576912.
- ↑ "Activation of somatostatin receptor 5 suppresses T-type Ca2+ channels through NO/cGMP/PKG signaling pathway in rat retinal ganglion cells". Neuroscience Letters 708. August 2019. doi:10.1016/j.neulet.2019.134337. PMID 31220522.
- ↑ "Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro". Molecular and Cellular Endocrinology 535. September 2021. doi:10.1016/j.mce.2021.111390. PMID 34224803.
- ↑ "Neuroprotective effect of the somatostatin receptor 5 agonist L-817,818 on retinal ganglion cells in experimental glaucoma". Experimental Eye Research 204. March 2021. doi:10.1016/j.exer.2021.108449. PMID 33465395.
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