Biology:Somatostatin receptor 5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene.[1]
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.[2]
Ligands
- Agonists
- L-817818 [3]
- Zavolosotine [4]
See also
References
- ↑ "Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization". Genomics 26 (3): 638–9. Aug 1995. doi:10.1016/0888-7543(95)80195-R. PMID 7607700.
- ↑ "Entrez Gene: SSTR5 somatostatin receptor 5". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6755.
- ↑ Zhang Y, Wu N, Li Q, Hu X, Wang L, Sun JG, Wang Z, Sun XH. Neuroprotective effect of the somatostatin receptor 5 agonist L-817,818 on retinal ganglion cells in experimental glaucoma. Exp Eye Res. 2021 Mar;204:108449. doi:10.1016/j.exer.2021.108449 PMID 33465395
- ↑ Ferrara-Cook C, Krasner AS. Somatostatin receptor type 5 agonist for the treatment of hyperinsulinism. WO 2022/177988
Further reading
- "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. 1992. doi:10.1073/pnas.89.1.251. PMID 1346068. Bibcode: 1992PNAS...89..251Y.
- "Primary structure of the gene encoding rat preprosomatostatin.". Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337–40. 1984. doi:10.1073/pnas.81.11.3337. PMID 6145156. Bibcode: 1984PNAS...81.3337M.
- "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.". Mol. Pharmacol. 45 (3): 417–27. 1994. PMID 7908405.
- "Characterization of cloned human somatostatin receptor SSTR5.". Mol. Pharmacol. 46 (2): 291–8. 1994. PMID 8078491.
- "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.". Biochem. Biophys. Res. Commun. 195 (2): 844–52. 1993. doi:10.1006/bbrc.1993.2122. PMID 8373420.
- "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.". Genomics 15 (2): 449–52. 1993. doi:10.1006/geno.1993.1088. PMID 8449518.
- "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157–63. 1997. doi:10.1006/bbrc.1997.6252. PMID 9125122.
- "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines.". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. 1997. doi:10.1210/jcem.82.6.4013. PMID 9177396.
- "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.". Genomics 42 (3): 499–506. 1997. doi:10.1006/geno.1997.4763. PMID 9205124.
- "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639–44. 1997. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.
- "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization.". J. Biol. Chem. 273 (33): 21416–22. 1998. doi:10.1074/jbc.273.33.21416. PMID 9694905.
- "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.". Mol. Endocrinol. 13 (1): 82–90. 1999. doi:10.1210/mend.13.1.0220. PMID 9892014.
- "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.". Diabetes 48 (1): 77–85. 1999. doi:10.2337/diabetes.48.1.77. PMID 9892225.
- "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.". J. Biol. Chem. 275 (11): 7862–9. 2000. doi:10.1074/jbc.275.11.7862. PMID 10713101.
- "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.". Science 288 (5463): 154–7. 2000. doi:10.1126/science.288.5463.154. PMID 10753124. Bibcode: 2000Sci...288..154R.
- "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. 2001. doi:10.1093/hmg/10.4.339. PMID 11157797.
- "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment.". J. Clin. Endocrinol. Metab. 86 (8): 3809–14. 2001. doi:10.1210/jcem.86.8.7787. PMID 11502816.
- "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. 2002. PMID 11753241.
- "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.". Virchows Arch. 440 (5): 461–75. 2002. doi:10.1007/s00428-002-0609-x. PMID 12021920.
External links
- "Somatostatin Receptors: sst5". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2435.
- somatostatin+receptor+5 at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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