Chemistry:L-AP4
From HandWiki
Short description: Chemical compound
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| Other names | L-2-Amino-4-phosphonobutyric acid |
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| Formula | C4H10NO5P |
| Molar mass | 183.100 g·mol−1 |
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L-AP4 (L-2-amino-4-phosphonobutyric acid) is a drug used in scientific research, which acts as a group-selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,[1] but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.[2][3][4][5]
References
- ↑ "The L-AP4 receptor". General Pharmacology 29 (2): 151–8. August 1997. doi:10.1016/S0306-3623(96)00417-X. PMID 9251893.
- ↑ "Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease". The Journal of Neuroscience 27 (25): 6701–11. June 2007. doi:10.1523/JNEUROSCI.0299-07.2007. PMID 17581957. PMC 6672706. https://hal.archives-ouvertes.fr/hal-00165896/document.
- ↑ "Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo". European Journal of Pharmacology 580 (1–2): 95–9. February 2008. doi:10.1016/j.ejphar.2007.10.030. PMID 18035348.
- ↑ "Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain". Neuroscience 158 (2): 875–84. January 2009. doi:10.1016/j.neuroscience.2008.10.042. PMID 19017536.
- ↑ "The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration". Brain Research 1282: 20–7. July 2009. doi:10.1016/j.brainres.2009.05.049. PMID 19481536.
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