Chemistry:LY2955303
From HandWiki
LY2955303 is a drug which acts as a potent and selective antagonist of the retinoic acid receptor γ (RARγ). It inhibits the signalling pathway of the pro-inflammatory mediator NF-κB and has been researched as a potential treatment for arthritis.[1][2]
References
- ↑ "Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design". Bioorganic & Medicinal Chemistry Letters 26 (14): 3274–3277. 15 July 2016. doi:10.1016/j.bmcl.2016.05.056. PMID 27261179.
- ↑ "Retinoic Acid Receptor Gamma (RARγ) Promotes Cartilage Destruction through Positive Feedback Activation of NF-κB Pathway in Human Osteoarthritis". Mediators of Inflammation 2022. 7 November 2022. doi:10.1155/2022/1875736. PMID 36387933.
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