Biology:Retinoic acid receptor gamma

Short description: Protein-coding gene in the species Homo sapiens

Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.^[1]^[2] Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma^[3] and its agonism of the gamma subtype is largely responsible for adapalene's observed effects.^[4]

Interactions

Retinoic acid receptor gamma has been shown to interact with NCOR1.^[5]

References

↑ "Entrez Gene: RARG retinoic acid receptor, gamma". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5916.
↑ "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research 19 (3): 573–8. Feb 1991. doi:10.1093/nar/19.3.573. PMID 1849262.
↑ "Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety". Clinical Interventions in Aging 1 (4): 327–48. 2006. doi:10.2147/ciia.2006.1.4.327. PMID 18046911.
↑ "Pharmacology of adapalene". The British Journal of Dermatology 139 (Suppl 52): 3–7. October 1998. doi:10.1046/j.1365-2133.1998.1390s2003.x. PMID 9990413.
↑ "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". The Journal of Biological Chemistry 274 (22): 15901–7. May 1999. doi:10.1074/jbc.274.22.15901. PMID 10336495.

"Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell 68 (2): 377–95. Jan 1992. doi:10.1016/0092-8674(92)90478-U. PMID 1310259.
"Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation". Molecular Endocrinology 6 (5): 667–76. May 1992. doi:10.1210/mend.6.5.1318502. PMID 1318502.
"RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites". Molecular and Cellular Biology 12 (7): 2976–85. Jul 1992. doi:10.1128/mcb.12.7.2976. PMID 1320193.
"Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes". Genomics 10 (4): 1061–9. Aug 1991. doi:10.1016/0888-7543(91)90199-O. PMID 1655630. https://dipot.ulb.ac.be/dspace/bitstream/2013/188897/1/Elsevier_172524.pdf.
"Murine isoforms of retinoic acid receptor gamma with specific patterns of expression". Proceedings of the National Academy of Sciences of the United States of America 87 (7): 2700–4. Apr 1990. doi:10.1073/pnas.87.7.2700. PMID 2157210. Bibcode: 1990PNAS...87.2700K.
"Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo". Molecular and Cellular Biology 10 (5): 2335–40. May 1990. doi:10.1128/mcb.10.5.2335. PMID 2157970.
"A functional retinoic acid receptor encoded by the gene on human chromosome 12". Molecular Endocrinology 4 (6): 837–44. Jun 1990. doi:10.1210/mend-4-6-837. PMID 2172793.
"A third human retinoic acid receptor, hRAR-gamma". Proceedings of the National Academy of Sciences of the United States of America 86 (14): 5310–4. Jul 1989. doi:10.1073/pnas.86.14.5310. PMID 2546152. Bibcode: 1989PNAS...86.5310K.
"Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid". Nature 378 (6558): 681–9. Dec 1995. doi:10.1038/378681a0. PMID 7501014. Bibcode: 1995Natur.378..681R.
"A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7". Nucleic Acids Research 21 (10): 2520. May 1993. doi:10.1093/nar/21.10.2520. PMID 7685085.
"Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts". Journal of Immunology 152 (3): 1419–27. Feb 1994. doi:10.4049/jimmunol.152.3.1419. PMID 8301142.
"Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation". The Journal of Biological Chemistry 272 (14): 9443–9. Apr 1997. doi:10.1074/jbc.272.14.9443. PMID 9083083.
"RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes". Journal of Cellular Physiology 175 (1): 68–77. Apr 1998. doi:10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A. PMID 9491782.
"Conformational adaptation of agonists to the human nuclear receptor RAR gamma". Nature Structural Biology 5 (3): 199–202. Mar 1998. doi:10.1038/nsb0398-199. PMID 9501913.
"Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma". The Journal of Biological Chemistry 273 (51): 34016–21. Dec 1998. doi:10.1074/jbc.273.51.34016. PMID 9852056.
"Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor". Cancer Research 58 (24): 5695–700. Dec 1998. PMID 9865725.
"Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor". The Journal of Biological Chemistry 274 (32): 22563–8. Aug 1999. doi:10.1074/jbc.274.32.22563. PMID 10428834.
"Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid". The EMBO Journal 19 (11): 2592–601. Jun 2000. doi:10.1093/emboj/19.11.2592. PMID 10835357.
"Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells". Experimental Cell Research 274 (1): 130–7. Mar 2002. doi:10.1006/excr.2001.5450. PMID 11855864.