Chemistry:Lapachol
Lapachol is a natural phenolic compound isolated from the bark of the lapacho tree.[1] This tree is known botanically as Handroanthus impetiginosus, but was formerly known by various other botanical names such as Tabebuia avellanedae.[2] Lapachol is also found in other species of Handroanthus.
Lapachol is usually encountered as a yellow, skin-irritating powder from wood. Chemically, it is a derivative of vitamin K.[3]
Once studied as a possible treatment for some types of cancer, the levels of lapachol required for cancer treatment are considered too toxic for use as an in vivo chemotherapy treatment.[4][5][6][7]
In 2024, A clinical trial published in the Journal of Cosmetic Dermatology determined that lower concentrations of lapachol were safe and efficacious in Facial Redness Reduction.[8]
See also
References
- ↑ Record, Samuel J.. "Lapachol" pages 17-19. In: Tropical Woods (1925).
- ↑ "Evolution of a Charismatic Neotropical Clade: Molecular Phylogeny of Tabebuia s.l., Crescentieae, and Allied Genera (Bignoniaceae)". Systematic Botany 32 (3): 650–659. 2007. doi:10.1600/036364407782250553. Bibcode: 2007SysBo..32..650G.
- ↑ Louis F.Fieser. The Scientific Method pages 163-191. Reinhold Publishing Corporation, New York, 1964
- ↑ "Fetal growth in rats treated with lapachol". Contraception 66 (4): 289–93. 2002. doi:10.1016/S0010-7824(02)00356-6. PMID 12413627.
- ↑ Oral toxicology studies with lapachol. Morrison, Robert K.; Brown, Donald Emerson; Oleson, Jerome J.; Cooney, David A. Toxicology and Applied Pharmacology (1970), 17(1), 1-11.
- ↑ "Toxicology of Lapachol in rats: embryolethality". Brazilian Journal of Biology 61 (1): 171–4. 2001. doi:10.1590/s0034-71082001000100021. PMID 11340475.
- ↑ "Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment". Phytotherapy Research 21 (7): 658–62. 2007. doi:10.1002/ptr.2141. PMID 17421057.
- ↑ "The Clinical Efficacy of Lapachol in Facial Redness Reduction". Journal of Cosmetic Dermatology 23 (11): 3662–3666. 2024. doi:10.1111/jocd.16602. PMID 39328086.
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