Chemistry:Linrodostat
From HandWiki
Short description: Chemical compound
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| Other names | BMS-986205; ONO 7701 |
| Routes of administration | Oral |
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| Formula | C24H24ClFN2O |
| Molar mass | 410.92 g·mol−1 |
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Linrodostat (development code BMS-986205) is an experimental drug being studied for its immunomodulating and antineoplastic activities.[1]
Linrodostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1).[2][3]
Linrodostat has entered clinical trials for a variety of cancer types including bladder cancer, head and neck cancer, endometrial cancer, gastric cancer, malignant melanoma, liver cancer, non-small cell lung cancer, and solid tumors.[4]
References
- ↑ "Linrodostat". NCI Drug Dictionary. National Cancer Institute. https://www.cancer.gov/publications/dictionaries/cancer-drug/def/linrodostat.
- ↑ "Preclinical Characterization of Linrodostat Mesylate, a Novel, Potent, and Selective Oral Indoleamine 2,3-Dioxygenase 1 Inhibitor". Molecular Cancer Therapeutics 20 (3): 467–476. March 2021. doi:10.1158/1535-7163.MCT-20-0251. PMID 33298590.
- ↑ "IDO Inhibitor Development Shows Fresh Signs of Life Across Tumor Types". October 31, 2019. https://www.onclive.com/view/ido-inhibitor-development-shows-fresh-signs-of-life-across-tumor-types.
- ↑ "Linrodostat". Adis Insight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800044556.
External links
- "Rapid Development of a Commercial Process for Linrodostat, an Indoleamine 2,3-Dioxygenase (IDO) Inhibitor". Organic Process Research & Development 23 (11): 2482–2498. 2019. doi:10.1021/acs.oprd.9b00359.
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