Chemistry:MB-3 (drug)
From HandWiki
Short description: Chemical compound
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| Formula | C9H12O4 |
| Molar mass | 184.191 g·mol−1 |
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MB-3 is a drug which acts as a potent and selective inhibitor of the histone acetyltransferase enzyme GCN5, which usually functions as a negative modulator of PGC-1α, and so MB-3 acts to indirectly activate PGC-1α. It is used in research into the role of the GCN5/PGC-1α pathway in the regulation of metabolism and cell differentiation.[1][2][3]
See also
References
- ↑ "Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5". Angewandte Chemie 43 (30): 3974–6. July 2004. doi:10.1002/anie.200453879. PMID 15274229.
- ↑ "Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties". Journal of Medicinal Chemistry 49 (23): 6897–907. November 2006. doi:10.1021/jm060601m. PMID 17154519.
- ↑ "Islet-1 synergizes with Gcn5 to promote MSC differentiation into cardiomyocytes". Scientific Reports 10 (1): 1817. February 2020. doi:10.1038/s41598-020-58387-8. PMID 32019948. Bibcode: 2020NatSR..10.1817X.
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