Chemistry:ML-154
From HandWiki
Short description: Chemical compound
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| Formula | C29H26BrN2PS |
| Molar mass | 545.48 g·mol−1 |
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ML-154 (NCGC-84) is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR.[1] In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism.[2]
See also
References
- ↑ "Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor". Journal of Medicinal Chemistry 56 (22): 9045–56. November 2013. doi:10.1021/jm400904m. PMID 24171469.
- ↑ "A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats". The Journal of Neuroscience 33 (24): 10132–42. June 2013. doi:10.1523/JNEUROSCI.4742-12.2013. PMID 23761908.
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