Chemistry:MS15203
From HandWiki
MS15203 (5-Methacrylamidoisophthalic acid) is an experimental drug which acts as a selective agonist for the neuropeptide receptor GPR171. In studies on mice it increases food intake and has analgesic effects, but shows sex-selective activity with greater effects in male mice than in female mice.[1][2][3]
References
- ↑ "Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake". Science Signaling 9 (430): ra55. May 2016. doi:10.1126/scisignal.aac8035. PMID 27245612.
- ↑ "GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice". Frontiers in Pain Research (Lausanne, Switzerland) 2. 2021. doi:10.3389/fpain.2021.695396. PMID 35295419.
- ↑ "A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice". Pharmacology, Biochemistry, and Behavior 224. March 2023. doi:10.1016/j.pbb.2023.173543. PMID 36933620.
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