Biology:GPR171
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
G-protein coupled receptor 171 is a protein that in humans is encoded by the GPR171 gene.[1][2] It has been recently deorphanised, with its endogenous agonist being a neuropeptide BigLEN which is a cleavage product of proSAAS. GPR174 has been found to be involved in processes such as pain, anxiety, and appetite regulation, as well as immune system function, and GPR174 agonists may represent a potential target for novel analgesic drugs. It seems to show sex-selective signalling, with effects seen in male mice often absent in female mice.[3][4][5][6][7][8][9][10][11][12]
Ligands
- Agonists
- BigLEN
- MS15203
References
- ↑ "A genetic selection for isolating cDNAs encoding secreted proteins". Gene 198 (1–2): 289–296. Dec 1997. doi:10.1016/S0378-1119(97)00330-2. PMID 9370294.
- ↑ "Entrez Gene: GPR171 G protein-coupled receptor 171". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=29909.
- ↑ "Orphan neuropeptides and receptors: Novel therapeutic targets". Pharmacology & Therapeutics 185: 26–33. 2018. doi:10.1016/j.pharmthera.2017.11.006. PMID 29174650.
- ↑ "Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171". The Journal of Pharmacology and Experimental Therapeutics 371 (1): 56–62. 2019. doi:10.1124/jpet.119.259242. PMID 31308196.
- ↑ "GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, but Not Female Mice". Frontiers in Pain Research (Lausanne, Switzerland) 2. 2021. doi:10.3389/fpain.2021.695396. PMID 35295419.
- ↑ "The GPR171 pathway suppresses T cell activation and limits antitumor immunity". Nature Communications 12 (1). 2021. doi:10.1038/s41467-021-26135-9. PMID 34615877. Bibcode: 2021NatCo..12.5857F.
- ↑ "Mice lacking proSAAS display alterations in emotion, consummatory behavior and circadian entrainment". Genes, Brain and Behavior 21 (7). 2022. doi:10.1111/gbb.12827. PMID 35878875.
- ↑ "GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice". Behavioural Pharmacology 33 (7): 442–451. 2022. doi:10.1097/FBP.0000000000000692. PMID 35942845.
- ↑ "A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice". Pharmacology, Biochemistry, and Behavior 224. 2023. doi:10.1016/j.pbb.2023.173543. PMID 36933620.
- ↑ "ProSAAS neuropeptides and receptors GPR171 and GPR83: Potential therapeutic applications for pain, anxiety, and body weight regulation". The Journal of Pharmacology and Experimental Therapeutics 392 (6). 2025. doi:10.1016/j.jpet.2025.103599. PMID 40450835.
- ↑ "GPR171 restrains intestinal inflammation by suppressing FABP5-mediated Th17 cell differentiation and lipid metabolism". Gut 74 (8): 1279–1292. 2025. doi:10.1136/gutjnl-2024-334010. PMID 40074327.
- ↑ "GPR171 is necessary for normal physiological functions and mood-related behaviors in males, but not females". Behavioural Brain Research 490. 2025. doi:10.1016/j.bbr.2025.115618. PMID 40318809.
Further reading
- "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. Sep 1995. PMID 7566098. https://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.
- "Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.". American Journal of Human Genetics 69 (4): 673–684. Oct 2001. doi:10.1086/323610. PMID 11524702.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–16903. Dec 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
 |  |
