Chemistry:Manogepix
From HandWiki
Short description: Chemical compound
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| Other names | E1210, APX001A |
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| Formula | C12H18N4O2 |
| Molar mass | 250.302 g·mol−1 |
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Manogepix (E1210) is an pyridine-isoxazole-based broad-spectrum antifungal.[1] Manogepix targets an enzyme involved in the post-translational modification of fungal proteins.
Manogepix is the active metabolite of the prodrug fosmanogepix.[2]
References
- ↑ "In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method". Diagnostic Microbiology and Infectious Disease 71 (2): 167–170. October 2011. doi:10.1016/j.diagmicrobio.2011.05.001. PMID 21696907.
- ↑ "Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, Demonstrates In Vitro Activity against Members of the Fusarium oxysporum and Fusarium solani Species Complexes". Antimicrobial Agents and Chemotherapy 65 (6). May 2021. doi:10.1128/AAC.02343-20. PMID 33722886.
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