Chemistry:NNI-351

NNI-351
Clinical data
Routes of; administration	By mouth
Identifiers
	IUPAC name 4-(3-Cyano-6-ethoxyquinolin-2-yl)-N-(2-fluorophenyl)-1,4-diazepane-1-carbothioamide;
CAS Number	929607-23-8 ;
PubChem CID	16661882;
ChemSpider	17594951;
UNII	97LG4X5P2E;
Chemical and physical data
Formula	C24H24FN5OS
Molar mass	449.55 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC1=CC2=C(C=C1)N=C(C(=C2)C#N)N3CCCN(CC3)C(=S)NC4=CC=CC=C4F;
	InChI InChI=1S/C24H24FN5OS/c1-2-31-19-8-9-21-17(15-19)14-18(16-26)23(27-21)29-10-5-11-30(13-12-29)24(32)28-22-7-4-3-6-20(22)25/h3-4,6-9,14-15H,2,5,10-13H2,1H3,(H,28,32); Key:RQXUPDSAFGWKMO-UHFFFAOYSA-N;

Short description: Chemical compound

NNI-351 is an orally active inhibitor of DYRK1A and neurogenesis enhancer which is under development by NeuroNascent, Inc. for the treatment of Down syndrome, depression, and post-traumatic stress disorder (PTSD).^[1]^[2] As of 2017, it is in the preclinical development stage, and has yet to progress to human clinical trials.^[1] In July 2022, NNI-351 was granted orphan drug status by the FDA for the treatment of Fragile X syndrome.^[3]

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Original source: https://en.wikipedia.org/wiki/NNI-351. Read more

Clinical data

Routes of administration	By mouth
Identifiers
IUPAC name 4-(3-Cyano-6-ethoxyquinolin-2-yl)-N-(2-fluorophenyl)-1,4-diazepane-1-carbothioamide
CAS Number	929607-23-8^Y
PubChem CID	16661882
ChemSpider	17594951
UNII	97LG4X5P2E
Chemical and physical data
Formula	C₂₄H₂₄FN₅OS
Molar mass	449.55 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCOC1=CC2=C(C=C1)N=C(C(=C2)C#N)N3CCCN(CC3)C(=S)NC4=CC=CC=C4F
InChI InChI=1S/C24H24FN5OS/c1-2-31-19-8-9-21-17(15-19)14-18(16-26)23(27-21)29-10-5-11-30(13-12-29)24(32)28-22-7-4-3-6-20(22)25/h3-4,6-9,14-15H,2,5,10-13H2,1H3,(H,28,32) Key:RQXUPDSAFGWKMO-UHFFFAOYSA-N