Chemistry:Nafimidone
From HandWiki
Short description: Chemical compound
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| Formula | C15H12N2O |
| Molar mass | 236.274 g·mol−1 |
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Nafimidone is an anticonvulsant drug of the imidazole class. It contains a naphthyl group. It seems to have been discovered by accident during a search for antifungal agents.
Synthesis
Its synthesis is straightforward displacement of imidazole of the activated chlorine atom of chloro-methyl-β-naphthylketone.
References
- ↑ "[N-Naphthacylimidazoles and N-((beta-naphthyl-beta-hydroxy)ethyl) imidazoles with anticonvulsant activity]". Bollettino Chimico Farmaceutico 120 (3): 185–90. March 1981. PMID 7272022.
- ↑ "1-(Naphthylalkyl)-1H-imidazole derivatives, a new class of anticonvulsant agents". Journal of Medicinal Chemistry 24 (1): 67–74. January 1981. doi:10.1021/jm00133a015. PMID 7205879.
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