Chemistry:Nardosinone
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| Preferred IUPAC name
(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one | |
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3D model (JSmol)
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| Properties | |
| C15H22O3 | |
| Molar mass | 250.338 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Nardosinone is a sesquiterpene and chemical constituent of Nardostachys jatamansi.[1] In in vitro studies, the compound has demonstrated concentration-dependent enhancement of bucladesine and staurosporine-induced neurite outgrowth.[2] Nardosinone has similarly been demonstrated to enhance NGF-mediated neurite outgrowth and synaptogenesis from PC12D cells.[3]
Additionally, nardosinone has demonstrated cytotoxic activity against cultured P-388 lymphocytic leukemia cells.[4]
References
- ↑ "Nardosinon, ein neuer Inhaltsstoff von Nardostachys chinensis Batalin" (in German). Tetrahedron Letters 6 (35): 3083–3084. 1965. doi:10.1016/S0040-4039(01)89226-1. PMID 5828044.
- ↑ "Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells". Developmental Brain Research 145 (2): 177–183. 2003. doi:10.1016/S0165-3806(03)00239-6. PMID 14604758.
- ↑ "Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells". Neuroscience Letters 273 (1): 53–56. 1999. doi:10.1016/S0304-3940(99)00629-1. PMID 10505650.
- ↑ "Cytotoxic sesquiterpenes from Nardostachys chinensis". Chemical & Pharmaceutical Bulletin 41 (6): 1183–1184. 1993. doi:10.1248/cpb.41.1183. PMID 8370115.
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