Chemistry:Nelonemdaz
From HandWiki
Short description: Chemical compound
 | |
| Legal status | |
|---|---|
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| UNII | |
| Chemical and physical data | |
| Formula | C15H8F7NO3 |
| Molar mass | 383.222 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Nelonemdaz is an experimental drug that works as a free radical reducer and selective antagonist of the NMDA receptor 2b. It is hypothesized to have neuroprotective effects in people who recently experienced a stroke.[1][2][3][4]
References
- ↑ Xu, Xiumei; Chen, Mingyu; Zhu, Dongya (13 October 2023). "Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical". Stroke and Vascular Neurology: svn–2023–002671. doi:10.1136/svn-2023-002671. PMID 37832977.
- ↑ Lee, Jin Soo; Lee, Ji Sung; Gwag, Byoung Joo; Choi, Dennis W; An, Chun San; Kang, Hyun Goo; Song, Tae-Jin; Ahn, Seong Hwan et al. (February 2023). "Abstract TP15: Rationale And Ongoing Status In A Phase 3 Trial Of Nelonemdaz, A Novel Neuroprotection Drug, For Patients With Acute Ischemic Stroke And Reperfusion". Stroke 54 (Suppl_1). doi:10.1161/str.54.suppl_1.TP15.
- ↑ Lee, Jin Soo; Lee, Ji Sung; Gwag, Byoung Joo; Choi, Dennis W.; An, Chun San; Kang, Hyun Goo; Song, Tae-Jin; Ahn, Seong Hwan et al. (31 January 2023). "The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz (RODIN) Trial: Protocol for a Double-Blinded Clinical Trial of Nelonemdaz in Patients with Hyperacute Ischemic Stroke and Endovascular Thrombectomy". Journal of Stroke 25 (1): 160–168. doi:10.5853/jos.2022.02453. PMID 36746385.
- ↑ Hong, Ji Man; Lee, Jin Soo; Lee, Yeong-Bae; Shin, Dong Hoon; Shin, Dong-Ick; Hwang, Yang-Ha; Ahn, Seong Hwan; Kim, Jae Guk et al. (November 2022). "Nelonemdaz for Patients With Acute Ischemic Stroke Undergoing Endovascular Reperfusion Therapy: A Randomized Phase II Trial". Stroke 53 (11): 3250–3259. doi:10.1161/STROKEAHA.122.039649. PMID 36065810.
 |  |
