Chemistry:Obicetrapib
From HandWiki
Short description: Chemical compound
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| Other names | TA-8995; AMG-899 |
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| Formula | C32H31F9N4O5 |
| Molar mass | 722.609 g·mol−1 |
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Obicetrapib is an experimental CETP inhibitor that is intended to treat dyslipidemia. In a clinical trial, as an add-on to statins, it decreased "LDL-C concentration (by up to 51%; P < 0.0001), the primary trial outcome. As compared with placebo, obicetrapib treatment also significantly (P < 0.0001) decreased apolipoprotein B (by up to 30%) and non-high-density lipoprotein cholesterol (non-HDL-C) concentration (by up to 44%), and significantly (P < 0.0001) increased HDL-C concentration (by up to 165%; the secondary trial outcomes)".[1][2] As of 2023, it is in a Phase III trial.[3]
References
- ↑ Ballantyne, Christie M.; Ditmarsch, Marc; Kastelein, John JP; Nelson, Adam J.; Kling, Douglas; Hsieh, Andrew; Curcio, Danielle L.; Maki, Kevin C. et al. (July 2023). "Obicetrapib plus ezetimibe as an adjunct to high-intensity statin therapy: A randomized phase 2 trial". Journal of Clinical Lipidology 17 (4): 491–503. doi:10.1016/j.jacl.2023.05.098.
- ↑ Nicholls, Stephen J.; Ditmarsch, Marc; Kastelein, John J.; Rigby, Scott P.; Kling, Douglas; Curcio, Danielle L.; Alp, Nicholas John; Davidson, Michael H. (August 2022). "Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial" (in en). Nature Medicine 28 (8): 1672–1678. doi:10.1038/s41591-022-01936-7. ISSN 1546-170X. https://www.nature.com/articles/s41591-022-01936-7.
- ↑ "NewAmsterdam Pharma concludes enrolment in LDL lowering therapy trial". Clinical Trials Arena. 26 July 2023. https://www.clinicaltrialsarena.com/news/newamsterdam-pharma-enrolment-ldl-lowering/.
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