Chemistry:Ocedurenone
From HandWiki
Short description: Chemical compound
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| Other names | KBP-5074 |
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| Formula | C28H30ClN5O2 |
| Molar mass | 504.03 g·mol−1 |
Ocedurenone, formerly known as KBP-5074,[1] is a nonsteroidal, selective mineralocorticoid receptor antagonist that is being developed to treat hypertension in patients with chronic kidney disease with less risk of hyperkalemia than existing treatments.[2][3] In 2023, KPB Biosciences entered in talks to sell the drug to Novo Nordisk for USD$1.3 billion. It is a small molecule drug administered orally and is in a Phase III trial that is scheduled to complete in 2024.[4][5]
References
- ↑ "Ocedurenone: A Novel Therapy for Uncontrolled Hypertension in Advanced Chronic Kidney Disease". 16 March 2023. https://www.emjreviews.com/nephrology/article/ocedurenone-a-novel-therapy-for-uncontrolled-hypertension-in-advanced-chronic-kidney-disease-j190123/.
- ↑ Pitt, Bertram; Jaisser, Frederic; Bakris, George (October 2021). "An evaluation of KBP-5074 in advanced chronic kidney disease with uncontrolled hypertension". Expert Opinion on Investigational Drugs 30 (10): 1017–1023. doi:10.1080/13543784.2021.1985462. ISSN 1744-7658. https://pubmed.ncbi.nlm.nih.gov/34595995/.
- ↑ Bakris, George; Pergola, Pablo E.; Delgado, Belkis; Genov, Diyan; Doliashvili, Tamar; Vo, Nam; Yang, Y. Fred; McCabe, James et al. (July 2021). "Effect of KBP-5074 on Blood Pressure in Advanced Chronic Kidney Disease: Results of the BLOCK-CKD Study". Hypertension 78 (1): 74–81. doi:10.1161/HYPERTENSIONAHA.121.17073.
- ↑ "Novo in $1.3B Deal Buys Late-Stage Hypertension Drug from Singapore Biotech". https://www.biospace.com/article/novo-in-1-3b-deal-buys-late-stage-hypertension-drug-from-singapore-biotech/.
- ↑ "Novo Nordisk in $1.3 bln deal to buy hypertension drug" (in en). Reuters. 16 October 2023. https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-13-bln-deal-buy-hypertension-drug-kbp-biosciences-2023-10-16/.
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