Chemistry:Orvepitant
From HandWiki
Short description: Chemical compound
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Formula | C31H35F7N4O2 |
Molar mass | 628.636 g·mol−1 |
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Orvepitant (GW823296) is a drug developed by GlaxoSmithKline which acts as a selective antagonist for the NK1 receptor.[1] It was under development as a potential antidepressant drug, and early stage human clinical trials showed it to have some antidepressant effects, though not with sufficient efficacy to justify further development for this application. It was however considered a successful proof of concept for NK1 antagonists as potential antidepressants, and efforts are continuing to find more potent compounds which might be more effective.[2]
References
- ↑ "Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate". Bioorganic & Medicinal Chemistry 21 (21): 6264–73. November 2013. doi:10.1016/j.bmc.2013.09.001. PMID 24075145.
- ↑ "Full central neurokinin-1 receptor blockade is required for efficacy in depression: evidence from orvepitant clinical studies". Journal of Psychopharmacology 27 (5): 424–34. May 2013. doi:10.1177/0269881113480990. PMID 23539641.
![]() | Original source: https://en.wikipedia.org/wiki/Orvepitant.
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