Chemistry:Oxazosulfyl
Oxazosulfyl is an insecticide that was developed by Sumitomo and introduced to the market in Japan in 2021 for use against insect pests on rice.[1] The molecule has two different sulfonyl groups.
Oxazosulfyl works by inhibiting the vesicular acetylcholine transporter (VAChT) and was allocated to IRAC group 37.[2] This inhibition results in rapid paralysis of the insect, which onsets a few minutes after application, and lasts for several days.
Oxazosulfyl is the first and until now only insecticide in the IRAC group 37. The class has not been given a name by IRAC, but Sumitomo propose the name "sulfyl" for the class.[1]
Oxazosulfyl is used mainly in rice seed boxes. It controls a broad spectrum of rice pests in the orders of hemiptera, lepidoptera, and coleoptera. Some of the target insects are the brown planthopper (Nilaparvata lugens), the white-backed planthopper (Sogatella furcifera), the small brown planthopper (Laodelphax striatellus) and the rice leaf beetle (Oulema oryzae).[3]
References
- ↑ 1.0 1.1 Ito, Mai; Nokura, Yoshihiko; Takahashi, Masaki; Kamezaki, Masashi; Sakamoto, Emiko; Nishimura, Shinya (5 July 2025). "Development of the insecticide oxazosulfyl". Journal of Pesticide Science 50 (3): 96–101. doi:10.1584/jpestics.J25-02. PMID 40910015. PMC 12405013. https://doi.org/10.1584/jpestics.J25-02.
- ↑ Goodchild, James; Chen, Ying-Ju; Blythe, Judith; Firth, Lucy C. (2024). "A novel class of insecticidal alkylsulfones are potent inhibitors of vesicular acetylcholine transport". Pesticide Biochemistry and Physiology 201. doi:10.1016/j.pestbp.2024.105854. ISSN 0048-3575. PMID 38685234. Bibcode: 2024PBioP.20105854G. https://doi.org/10.1016/j.pestbp.2024.105854.
- ↑ Kamezaki, Masashi; Otsuki, Junko; Natsuhara, Katsuya (18 January 2024). "Insecticidal activity against rice pest of oxazosulfyl, a novel sulfyl insecticide". Journal of Pesticide Science 49 (1): 31–37. doi:10.1584/jpestics.D23-057. PMID 38450091. PMC 10912969. https://doi.org/10.1584/jpestics.D23-057.
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