Chemistry:Pifithrin
From HandWiki
Pifithrin-α (chemical name 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide[1]) is a chemical compound which acts as an inhibitor of the tumour-suppressing and epileptogenic protein p53.[2][3] It has a molecular weight of 367.30 and is soluble in DMSO up to 20 mg/mL. Its melting point is 192.1-192.5 °C.
References
- ↑ "sigmaaldrich.com". https://www.sigmaaldrich.com/GB/en/product/sigma/p4359.
- ↑ George, SL; Parmar, V; Lorenzi, F; Marshall, LV; Jamin, Y; Poon, E; Angelini, P; Chesler, L (May 2020). "Novel therapeutic strategies targeting telomere maintenance mechanisms in high-risk neuroblastoma". J Exp Clin Cancer Res 39 (1): 78. doi:10.1186/s13046-020-01582-2. PMID 32375866.
- ↑ Gupta, V; Singh, S; Singh, TG (Nov 2024). "Pervasive expostulation of p53 gene promoting the precipitation of neurogenic convulsions: A journey in therapeutic advancements". Eur J Pharmacol 983. doi:10.1016/j.ejphar.2024.176990. PMID 39251181.
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