Chemistry:Ro5-3335

From HandWiki

Ro5-3335 is an experimental drug from the benzodiazepine family which acts as a selective inhibitor of the protein Runt-related transcription factor 1 (RUNX1). Inhibition of this protein is useful in numerous medical applications, and Ro5-3335 has beneficial effects against diverse conditions including HIV infection, leukemia and some other forms of cancer, recovery following heart attack, acute kidney injury, and some types of retinopathy.[1][2][3][4][5][6][7][8][9]

References

  1. ↑ "Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction". Proceedings of the National Academy of Sciences of the United States of America 109 (36): 14592–14597. September 2012. doi:10.1073/pnas.1200037109. PMID 22912405. Bibcode: 2012PNAS..10914592C. 
  2. ↑ "Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA". PLOS Pathogens 10 (3). March 2014. doi:10.1371/journal.ppat.1003997. PMID 24651404. 
  3. ↑ "Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy". Scientific Reports 10 (1): 20554. November 2020. doi:10.1038/s41598-020-77254-0. PMID 33257736. 
  4. ↑ "Runt-related transcription factor 1 (Runx1) aggravates pathological cardiac hypertrophy by promoting p53 expression". Journal of Cellular and Molecular Medicine 25 (16): 7867–7877. August 2021. doi:10.1111/jcmm.16704. PMID 34190420. 
  5. ↑ "Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension". Cardiovascular Research 118 (16): 3211–3224. December 2022. doi:10.1093/cvr/cvac001. PMID 35018410. 
  6. ↑ "Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction". Cardiovascular Research 119 (16): 2663–2671. December 2023. doi:10.1093/cvr/cvad107. PMID 37433039. 
  7. ↑ "Pharmacological inhibition of RUNX1 reduces infarct size after acute myocardial infarction in rats and underlying mechanism revealed by proteomics implicates repressed cathepsin levels". Functional & Integrative Genomics 24 (3): 113. June 2024. doi:10.1007/s10142-024-01391-2. PMID 38862712. 
  8. ↑ "RUNX1 expression is regulated by a super-enhancer and is a therapeutic target in adult T-cell leukemia/lymphoma". Leukemia & Lymphoma 65 (14): 2116–2128. December 2024. doi:10.1080/10428194.2024.2393258. PMID 39219309. 
  9. ↑ "Runt-related transcription factor 1 (RUNX1) is a mediator of acute kidney injury". The Journal of Pathology 264 (4): 396–410. December 2024. doi:10.1002/path.6355. PMID 39472111. 



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