Chemistry:Ro67-4853
From HandWiki
Short description: Chemical compound
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| Formula | C19H19NO4 |
| Molar mass | 325.364 g·mol−1 |
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Ro67-4853 is a drug used in scientific research, which acts as a selective positive allosteric modulator for the metabotropic glutamate receptor subtype mGluR1.[1][2][3] It was derived by modification of the simpler compound Ro01-6128, and has itself subsequently been used as a lead compound to develop a range of potent and selective mGluR1 positive modulators.[4][5]
See also
C19H19NO4
References
- ↑ "Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site". Proceedings of the National Academy of Sciences of the United States of America 98 (23): 13402–7. November 2001. doi:10.1073/pnas.231358298. PMID 11606768. Bibcode: 2001PNAS...9813402K.
- ↑ "A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators". Molecular Pharmacology 70 (2): 616–626. August 2006. doi:10.1124/mol.105.021857. PMID 16645124. http://pdfs.semanticscholar.org/3c5d/1685fa51ec475d1ee0b1500af13d3150a182.pdf.
- ↑ "Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells". Neuropharmacology 55 (4): 419–27. September 2008. doi:10.1016/j.neuropharm.2008.06.047. PMID 18625258.
- ↑ "9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers". Bioorganic & Medicinal Chemistry Letters 15 (20): 4628–31. October 2005. doi:10.1016/j.bmcl.2005.05.135. PMID 16099654.
- ↑ "Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers". Bioorganic & Medicinal Chemistry Letters 19 (6): 1666–9. March 2009. doi:10.1016/j.bmcl.2009.01.108. PMID 19233648.
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