Chemistry:SM-130686
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C22H23ClF3N3O3 |
| Molar mass | 469.89 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
SM-130686 is a small-molecule drug which acts as a potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and growth hormone secretagogue,[1] with around half the potency of the endogenous agonist ghrelin as a stimulator of growth hormone release.[2][3] It produces dose-dependent increases in muscle mass and decrease in body fat, and is under investigation for the treatment of growth hormone deficiency and other medical conditions.[4] Concerns about its potential use as a performance-enhancing drug for athletes have led to the development of urine tests for SM-130686 and other GHSR agonists, even though no drugs from this class have yet progressed to clinical use.[5]
See also
- List of growth hormone secretagogues
References
- ↑ "Structure-activity relationships of the oxindole growth hormone secretagogues". Bioorganic & Medicinal Chemistry Letters 15 (7): 1789–92. April 2005. doi:10.1016/j.bmcl.2005.02.042. PMID 15780607.
- ↑ "Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686". The Journal of Endocrinology 171 (3): 481–9. December 2001. doi:10.1677/joe.0.1710481. PMID 11739014.
- ↑ "Oxindole derivatives as orally active potent growth hormone secretagogues". Journal of Medicinal Chemistry 44 (26): 4641–9. December 2001. doi:10.1021/jm0103763. PMID 11741481.
- ↑ "Synthesis and pharmacological profile of an orally-active growth hormone secretagogue, SM-130686". Combinatorial Chemistry & High Throughput Screening 9 (3): 187–96. March 2006. doi:10.2174/138620706776055548. PMID 16533152.
- ↑ "Determination of therapeutics with growth-hormone secretagogue activity in human urine for doping control purposes". Rapid Communications in Mass Spectrometry 20 (22): 3393–402. 2006. doi:10.1002/rcm.2758. PMID 17051614. Bibcode: 2006RCMS...20.3393T.
 |  |
